The aim of the present study was designed to evaluate the antidepressant activities of Solanum violaceum using different animal models. Antidepressant activity was tested using various methods like locomotor activity, forced swim test and tail suspension test method. Pharmacological studies have been conducted to the ethanol extracts of Solanum violaceum leaves to evaluate their effects on the central nervous system (CNS). Animals treated with all three doses of ethanolic extract of leaves of Solanum violaceum (100, 200 and 400 mg/kg) witnessed an increased locomotor activity and a decrease in their immobility times in forced swim test and tail suspension tests which was significant when compared with control. Similarly, animals treated with imipramine (15 mg/kg), as expected showed a significant decrease in the immobility time.
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